Does Ozempic Lower Estrogen if You Have PCOS?

If you’ve been following the Ovafit blog for a while, you know that GLP-1 medications aren’t the only way to reach your weight loss goals. But it can sometimes feel that way, right? You become frustrated and discouraged, and anything that promises “instant results” begins to sound a little bit enticing. But, here’s the thing: polycystic ovary syndrome (PCOS) is complex, meaning it affects every part of your body. From irregular periods and fatigue to excess hair growth and stubborn weight gain, symptoms of PCOS are anything but simple. And for about 80% of women with PCOS, insulin resistance plays a major role in those frustrating symptoms—especially the weight that just won’t budge. 

That’s why some doctors are now prescribing medications like Ozempic to help manage PCOS symptoms. You might be thinking, “Wait, isn’t Ozempic for Type 2 diabetes?” Yep! But it’s being prescribed off-label to help people with PCOS improve insulin sensitivity, regulate blood sugar, and support weight loss. But here’s what gets lost in translation: Ozempic doesn’t just influence insulin. It can impact your hormones, too, including estrogen. And for someone with PCOS, this is a big deal.

So, is Ozempic marketed as a medication to improve insulin resistance? Yes. But for women with PCOS, this can cause a ripple effect and potentially influence estrogen levels (and other hormones) in the process. However, you aren’t on this journey alone! Today’s post is dedicated to breaking down exactly how Ozempic can affect estrogen in Cysters. From side effects to helpful strategies in reducing these side effects, let’s support your PCOS healing journey together.

Does Ozempic Lower Estrogen If You Have PCOS?

Ozempic doesn’t directly lower estrogen, but it also doesn’t target hormone imbalance at the root, either. It works by improving insulin sensitivity, which can indirectly impact hormone levels since insulin resistance is a key player in hormonal disruption. Does this sound promising? Sure! But, even still, it isn’t a specified treatment for balancing hormones.

Here’s how it works: Semaglutide, the active ingredient in Ozempic, is a GLP-1 receptor agonist that helps your body become more sensitive to insulin. That’s a big deal for women with PCOS! When your body pumps out too much insulin (a telltale sign of insulin resistance), it overstimulates your ovaries to produce more androgens (AKA male hormones like testosterone). And guess what? Those androgens are then converted into estrogen.

It’s kind of like a hormone hamster wheel, spinning in circles and making it hard to break free. But if you’re wondering if GLP-1 medications may be your golden ticket to relief, it’s important to understand that any benefits are temporary. I’m a strong advocate for addressing PCOS symptoms by working with your body, not against it.  

Natural approaches such as diet and exercise, strategic supplements, and herbs that balance hormones can all be part of a sustainable, side-effect-free plan to help you feel better and reverse your PCOS naturally. As a PCOS dietitian, it’s my job to give you all the tools and information you may need to make a decision that best suits your journey. That said, let’s look at all the different ways ozempic can affect estrogen in women with PCOS. 

How Does Ozempic Affect Estrogen If You Have PCOS?

It lowers insulin production. 

Ozempic is an insulin-sensitizing medication, which means it helps reduce the amount of insulin your body produces. This means less ovarian overstimulation, fewer androgens, and less excess estrogen circulating in your system. This process can also support weight loss, which further helps bring those hormones back into balance.

It reduces fat tissue. 

Women with PCOS who are overweight or obese often experience higher levels of estrogen—and it’s not just about hormone production. Estrogen, especially estrone, tends to get stored in fat tissue. And since PCOS and insulin resistance often lead to stubborn weight gain (hello, PCOS belly), that extra fat can send out inflammatory estrogen-like signals that make symptoms worse. 

This is where Ozempic comes in. By improving insulin sensitivity and helping reduce weight (especially around the midsection), Ozempic can help lower estrogen levels stored in fat tissue. So, while its main job is targeting insulin, one of the effects can include a shift in hormone levels—such as a reduction in excess estrogen.

It helps restart ovulation. 

One of the most common hormone imbalances with PCOS is estrogen dominance, and it often comes down to one key issue: irregular ovulation. When you don’t ovulate, your body doesn’t make enough progesterone, and without progesterone to keep estrogen in check, your levels can spiral.

When weight gain and insulin resistance are addressed (like with Ozempic), many women start ovulating more regularly. And when ovulation returns, natural progesterone production kicks in, helping to rebalance estrogen levels and reduce symptoms of estrogen dominance. 

It reduces inflammation. 

Chronic inflammation is one of the biggest root causes of PCOS, and it can seriously mess with how your body processes estrogen. When inflammation is high, especially in the liver (which plays a key role in hormone metabolism), estrogen can start to build up in the body instead of being properly cleared out. That buildup can lead to symptoms like heavy periods, mood swings, and hormonal acne. 

Ozempic may help lower overall inflammation and support better metabolic and liver health. This in turn helps your body process and eliminate excess estrogen more efficiently. The result? A more balanced cycle and fewer estrogen-related symptoms.

What Are The Long-Term Side Effects Of Ozempic For PCOS?

Gastrointestinal Side Effects

Some of the most common side effects of taking Ozempic include nausea, constipation, diarrhea, and even vomiting—especially during those first few weeks or months. While many people find these symptoms fade over time, for some, they can stick around longer than expected. 

In fact, some people experience the development of gastroparesis (stomach paralysis), leading to food and digestive issues. These side effects aren’t usually dangerous, but they can be seriously uncomfortable. And if they start interfering with your ability to eat enough or absorb nutrients, they could lead to malnutrition, which can take a toll on your overall health and hormone balance. 

Potential Muscle Loss

When taking weight loss meds like Ozempic, it’s easy to focus on the scale. But, let’s not forget what’s actually being lost. One study showed that 39% of weight loss can be lean muscle mass if you’re not staying on top of your protein intake and strength workouts. Yep, that muscle you’ve worked so hard to build with Pilates and slow-weighted workouts? It can disappear faster than you think. 

And here’s why that matters, especially for Cysters: muscle is your metabolic BFF. It helps balance blood sugar, boosts metabolism, and supports insulin sensitivity. So if you lose too much muscle while taking Ozempic—and eventually stop the medication—it could actually worsen insulin resistance over time. 

Gallbladder Issues

Your gallbladder might be small, but it plays a pretty big role in your gastrointestinal system. More specifically, It stores and releases bile, a fluid that helps you break down fats after a meal.  When you’re taking GLP-1 agonists like Ozempic, especially during rapid weight loss, there’s a higher risk of developing gallstones or gallbladder inflammation. 

And here’s where it gets a little tricky for us Cysters: PCOS already increases your risk of gallbladder issues thanks to elevated estrogen levels and insulin resistance. So, stacking a GLP-1 on top of that? It could compound that risk. 

Signs of gallbladder problems can include bloating, indigestion, nausea, upper abdominal pain (especially on the right side), and even discomfort that radiates to your back or shoulder. If you notice any of these while taking a GLP-1, it’s worth bringing up to your doctor. Your PCOS body deserves to feel supported from every angle. 

Pancreatitis

While it’s rare, one potential long-term side effect of taking Ozempic is acute pancreatitis. This is especially true if you already have high triglycerides or gallbladder issues (which are already more common in women with PCOS). 

Your pancreas is the organ that plays a big role in digestion and blood sugar balance (hello, insulin!). But when it becomes inflamed, it can cause some serious discomfort. Symptoms of pancreatitis include upper abdominal pain, pain after eating, nausea, bloating, fever, and even a tender or swollen belly.

Thyroid Conditions

While more research and clinical studies are still needed, some early animal studies suggest that GLP-1 medications like Ozempic might be linked to an increased risk of thyroid tumors. In these clinical trials, rats developed thyroid growths after being given GLP-1 drugs. Note: we yet know how this translates to humans, but it’s important to take into consideration. 

It’s important, especially for women with PCOS, to pay close attention to Ozempic’s negative impact on the thyroid. Why? Because PCOS and thyroid issues like hypothyroidism are already closely connected. Since your thyroid is a major hormone powerhouse, anything that disrupts it can create a domino effect throughout your body. 

If you’re thinking of starting a GLP-1 medication, it’s always a good idea to talk to your doctor, especially if you have a personal or family history of thyroid cancers or disorders. Your hormones work hard enough as it is; let’s protect them where we can. 

How to Avoid Ozempic Side Effects for PCOS

It’s important to remember that GLP-1 medications are not officially FDA-approved as a treatment of PCOS. So, while I’m not here to tell you what route to take, I am here to assist you in avoiding the side effects if you are on Ozempic. Or, even if you’re not! These tips are important for women in any walk of their PCOS journey. 

Prioritize a protein-rich, gluten- and dairy-free anti-inflammatory diet. 

What you eat can make a huge difference in how you feel, especially when managing PCOS and taking a medication like Ozempic. 

Even if you’re not on Ozempic, following a gluten- and dairy-free anti-inflammatory diet can work wonders for your hormones. But if you are using Ozempic, it becomes even more important to focus on protein-rich meals. Protein protects your muscle mass, keeps your energy steady, and ensures your body gets the nutrients it needs to feel strong and supported. 

Not sure what to cook? I’ve got you! Inside The Cysterhood app, you’ll find hundreds of easy, delicious PCOS-friendly recipes. Think comfort food classics but with hormone-friendly upgrades. 

Stay hydrated and add electrolytes. 

Staying hydrated and keeping your electrolytes balanced is so important when you’re taking Ozempic, especially if you’re also managing PCOS. It’s one of the simplest (and most overlooked!) ways to reduce side effects and feel your best.

Ozempic can cause symptoms like nausea and dizziness, but drinking enough water can help alleviate these. It also beat that foggy, lightheaded feeling and keeps your digestion moving. Since GLP-1 meds like Ozempic slow down digestion, constipation can become an secondary issue. Staying hydrated supports regular movements, which is key for clearing out excess estrogen and keeping hormones in balance. 

And don’t forget your electrolytes—sodium, potassium, and magnesium help prevent fatigue, muscle cramps, irritability, and brain fog. Try adding a pinch of sea salt to your water, sipping on an electrolyte drink, or taking a high-quality supplement (like our MetaMulti Vitamin) to stay fully supported. 

Take supplements to fill nutrient gaps.

It’s normal to eat less while taking Ozempic—it’s part of how the medication works. But that also means you might not be getting all the nutrients your body needs to thrive. And if you have PCOS, you already know that nutrient absorption can be a struggle thanks to inflammation, gut imbalances, and insulin resistance. 

That’s why it’s so important to support your body with the right supplements. Ovafit’s MetaMulti is a daily multivitamin made for women with PCOS. It’s designed to fill those nutritional gaps and give your body exactly what it needs without any unnecessary fillers or ingredients that throw your hormones out of whack. 

When your meals get smaller, your supplements matter more. MetaMulti has your back! 

Add slow-weighted training to your weekly routine.

We’ve already talked about how Ozempic can lead to muscle loss, which is not ideal when you’re trying to manage insulin resistance and keep your metabolism strong. That’s why strength training is so important while taking a GLP-1. 

To protect the muscle you’ve worked hard to build (and to support your body long after Ozempic), aim to incorporate slow-weighted strength training 2 to 4 times a week. It doesn’t have to be intense or overwhelming—just consistent, intentional movement that work with your PCOS, not against it. 

Need help getting started? You’ll find fun, effective, and PCOS-friendly workouts on The Cysterhood app. These workouts are all designed to help you feel strong, confident, and supported at every step of your healing journey. 

Avoid drinking alcohol. 

I already encourage Cysters to limit alcohol since it can throw your cortisol levels out of balance (hello, stress hormone spike). But if you’re taking Ozempic, skipping the wine is even more important. 

Drinking alcohol while on Ozempic can raise your risk of pancreatitis, which is something no one wants to deal with. It can also cause low blood sugar (hypoglycemia) and worsen gastrointestinal issues. Plus, alcohol is super dehydrating, which means you’ll need to drink even more water to stay balanced. It can leave you feeling sluggish, bloated, and way more likely to reach for high-fat, sugary foods the next day. 

If you’re serious about supporting your hormones, losing weight, and feeling your best while managing PCOS, avoiding alcohol is one of the simplest and most impactful things you can do. Your body (and future self) will thank you! 

Get long-lasting results to manage your PCOS without the scary side effects.

The more you dig into the research behind semaglutide medications, the more you might start to question whether the potential side effects are worth it. While it may promise fast results, those results often don’t last. And the long-term effects? They might stick around longer than you’d like. It’s really important to remember that GLP-1 medications are not meant to be permanent solutions, and all medications should have an exit plan. You may see results initially, but without long-term support and lifestyle changes, these results eventually fade. I don’t tell you this to shame or judge—you simply deserve a plan that sets you up for lasting success.

If you’re ready to tackle one of the root causes of PCOS—insulin resistance—in a more natural and sustainable way, it’s worth considering a GLP-1 booster like Berberine Advanced. Berberine is a natural compound that supports insulin sensitivity, curbs cravings, and helps bring your hormones back into balance—without the needles or harsh side effects. 

At Ovafit, we created Berberine Advanced specifically for women with PCOS. Each 550 mg capsule is designed to be taken just twice a day. And here’s what makes it even more special: Ovafit is home to the only NSF-certified PCOS supplement line on the market. That means every ingredient is third-party tested for quality, purity, and effectiveness. 

If you’re looking for a natural and effective way to support your PCOS healing journey, Berberine Advanced might be the perfect place to start.